There is a lot to do at Key Largo. The first and the foremost that appeals to the tourists here is of course the water sports. The divers enjoy their vacation at Key Largo to the maximum and have the option to borrow scuba diving equipments and explore the underwater world here. The first underwater park in the United States, John Pennelam Coral Reef Park is also on the island of Key Largo. Other water activities that can be enjoyed at the island include water skiing, scuba diving, parasailing, fishing, boating, snorkeling etc.

Wildlife and nature lovers can visit the Everglades National Park, Wild bird Centre or get a glimpse of the crocodiles at the Crocodile Lake National Wildlife Refuge which can seen from a distance only. The children might enjoy playing at the various parks or can be taken to a visit to Jacob's Aquatics Center. The water park offers good thrill to the children and keeps them excited. The Spiegel Grove wreck site and other such sites are some of the other things which can be seen here.

Key Largo offers a good nightlife to the tourist who can visit the clubs and the bars here. There are a number of stores also which appeals to the shopping addicts who can shop for gifts and souvenirs from here.